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  • The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) of more than 27, so long as they also are afflicted by weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment choice for chronic weight management for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes demonstrated that patients had a typical weight loss of four.1% as opposed to participants who were given placebos) after a 12- month period, while a different study involving patients with diabetes had a normal weight loss of 2% over treatment with placebo at twelve months. Using two separate drugs to lose weight naturally can be very effective there are combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done in order that the public knows the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies have been in business to earn money and that they would say everything to keep people on his or her medications. Researchers found out that participants taking this drug for the year, dropped excess weight within a month and have kept the load off during the entire 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, that might make them far better and safer. Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular could be the fact that as of right now there aren't long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug can also raise blood pressure and heartrate, and mustn't be used in individuals with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. Follow Crash Test Addict on: Twitter Facebook Linkedin Wordpress

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